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Postdoctoral Fellow Ultra-High Throughput Mass Spectrometry

Merck

Merck

West Point, PA, USA
Posted on Saturday, April 6, 2024

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Project Title: Understanding and exploiting the capabilities of ultra-high throughput mass spectrometry (uHT-MS)

Position Overview: We are seeking a talented and motivated Postdoctoral Scientist passionate about the application of the latest analytical technologies within pharmaceutical drug discovery. Working within the DATA (Data Science, Automation, & Translational Analytics) organization in the Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) Department, you will be building a foundational understanding of Acoustic Ejection-Mass Spectrometry (AE-MS). AE-MS brings data acquisition times down by 10-100x or more compared with traditional discovery high throughput quantitative LC-MS/MS approaches opening up possibilities for redefining not just bioanalytical strategy but also how experiments are designed and executed. Based at our West Point, Pennsylvania facility, you will have access to a brand new state-of-the-art automated laboratory containing the latest AE-MS technologies coupled to automated platforms for development and execution of assay workflows. Taking the foundational knowledge you build; you will be working with cross-functional teams and as part of a research collaboration with the instrument vendor to define strategies for rapid AE-MS method development and applying this to the development of new workflows within Drug Metabolism and Pharmacokinetics (DMPK).

Responsibilities include but are not limited to:

Develop a strategy for rapid AE-MS method optimization and apply it to real-world bioanalytical applications in DMPK for an array of assay types.

Design and execution of experiments to build Structure Activity Relationship for mass spectrometry ionization efficiency. You will work with chemistry, automation and compound logistics, bioanalytic and data science teams.

Develop an understanding for application of AE-MS in real-time analysis of enzyme kinetic experiments.

Continue to build upon our company's research collaboration with the instrument vendor.

Actively engage in the education and training of our company's colleagues.

Write, publish and present (internally and externally) findings.

Education Minimum Requirement:

  • Candidates must currently hold a PhD or will you have completed your PhD within six months in Chemical, analytical/ bioanalytical or biological sciences.

Required Experience and Skills:

  • Mass Spectrometry
  • Analytical/bioanalytical science
  • Basic statistical analysis and data handling skills
  • Must have strong organizational skills to deal with large amounts of data.
  • High attention to detail; scientific and technical problem solving.
  • The candidate must exhibit excellent communication and collaborative skills for working in cross-functional multi-disciplinary teams.

Preferred Experience and Skills:

  • Design of Experiments (DoE) experience
  • Previous experience with high throughput technologies and laboratory automation
  • Data science and programming (R, Python, etc.)

Resume keywords for recruiting team:

Mass spectrometry

Automation

Data processing

Data science

MRLpostdoc

#EBRG

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Employee Status:

Regular

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Not Applicable

Shift:

Valid Driving License:

Hazardous Material(s):

Job Posting End Date:

06/19/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.


Job Posting End Date:06/19/2024


A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.


Requisition ID:R287742