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Senior Scientist (Discovery Pharmaceutical Science - Onsite)



Boston, MA, USA
Posted on Wednesday, May 22, 2024

Job Description

Are you passionate about revolutionizing drug delivery and shaping the future of pharmaceutical sciences? Join our dynamic and multidisciplinary research group that is at the forefront of drug discovery and development.

Our company's Research Laboratories Boston is focused on driving discovery research. Our multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with our company's world-class R&D expertise in small molecules, peptides, biologics and nucleic acids. Located within the heart of the Massachusetts biomedical community, research conducted in our laboratories spans exploratory biology through early clinical development and is an integral part of our company's powerful world-class network of drug and vaccine discovery.

Discovery Pharmaceutical Sciences (DPS) is a multi-disciplinary research group that enables drug discovery and drug product development through application of pharmaceutical science and drug delivery research from target identification through clinical candidate selection for both small and large molecules.

DPS influences molecular design of novel therapeutics through physicochemical property profiling, de-risking strategies, and communication across functions and downstream to development partners. We further utilize our expertise to develop and study prototype formulations intended for clinical use, and deliver robust Good Laboratory Practice formulations. In aggregate, our team enables the transition of the right molecules from discovery to clinical formulation development with clinical formulation strategies in place. This position offers the unique opportunity to contribute to the development of innovative drug delivery technologies and the advancement of novel drug products through solving unique challenges in delivering diverse modalities and driving scientific rigor to maintain the leading position of DPS in pharmaceutics assessment.

DPS team in Boston, MA is seeking a highly motivated Senior Scientist for a lab-based role with creative passion for identifying and applying effective drug delivery technologies and pharmaceutics concepts to rapidly progress from idea conception to in-vitro & in-vivo evaluation of novel drug candidates.

Primary responsibilities include:

  • Design and execute physicochemical characterization and formulation development experiments of diverse modalities for pharmacology, toxicology and FIH studies.

  • Direct and advocate pipeline-focused novel drug delivery technologies and strategies across the Discovery portfolio and into Development, impacting across functional areas.

  • Conduct developability assessment of new drug candidates.

  • Perform technical and trend analysis of the data and communicate data to project teams and functional management.

  • As part of our Company’s emphasis on innovation, the successful candidate also will actively explore external (commercial and academic) opportunities to engage new technologies related to drug delivery, pharmaceutics, and other areas relevant to our company's drug discovery/development programs.

  • Limited travel to scientific conferences and broader Pharmaceutical Sciences department meetings (< 5%).

Education and Experience:

  • Ph.D. in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical / Biochemical/ Biomedical engineering, or related disciplines or with 0+ years of industrial experience or a M.S. with 4+ years of relevant industrial experience.

Required Experience and Skills:

  • Practical experience and/or a strong interest to learn and implement new drug delivery and analytical technologies.

  • Practical experience working within cross-disciplinary project teams and achieving results in a matrix environment.

  • Strong organizational and technical problem-solving skills and excellent management in driving results and innovation.

  • Ability to work independently, as well as collaboratively in a fast-paced environment.

Desired Experience and Skills:

  • Demonstrated experience solving program trials by leveraging strong scientific fundamentals in related subject areas including organic chemistry, analytical chemistry, physical chemistry, biopharmaceutics, process development, and/or engineering.

  • Experience in pre-clinical / clinical formulation development and physicochemical characterization and drug delivery of small and/or large molecules.

  • Advanced data analysis and visualization skills.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement​

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Applicable


Not Indicated

Valid Driving License:


Hazardous Material(s):

Handling of various drug substances & chemicals

Job Posting End Date:


*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date:06/13/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R295010